Important Medical Disclaimer
This calculator is an educational and clinical decision support tool. Results DO NOT replace professional medical evaluation, laboratory tests, or clinical judgment. Always consult a qualified healthcare professional for diagnosis, treatment, and clinical decisions. Calculations are based on scientifically validated formulas but may not be applicable to all patients.
Benzodiazepine Equivalence Calculator
Calculate equivalent doses between different benzodiazepines using diazepam as reference.
Input Data
How It Works
Equivalencies are based on relative potency compared to diazepam (10mg). For example, alprazolam 0.5mg ≈ diazepam 10mg.
Clinical Use
Useful for safe switching between benzodiazepines, gradual reduction (tapering), and dose adjustment in different clinical contexts.
Frequently Asked Questions
Why use diazepam as reference?
Diazepam is the most studied benzodiazepine and serves as the standard for potency and equivalence comparisons.
Can I switch benzodiazepines directly?
Not abruptly. Switching should be gradual, clinically monitored, considering half-life and withdrawal symptoms.
Is alprazolam more potent?
Yes, alprazolam is about 20x more potent than diazepam (0.5mg alprazolam ≈ 10mg diazepam).
How to taper benzodiazepines?
Gradual reduction of 10-25% every 1-2 weeks is recommended, often converting to diazepam first due to its long half-life.